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Statistical analysis Similar studies were used to determine the sample size of this study

After blocking with goat serum for 30 min, the cells were incubated with primary antibody against SMAD3 (dilution ratio: 1:500

Senolytic agents exhibit limited specificity, potentially eliminating senescent cell subpopulations with tissue-repair functions during clearance

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The corresponding quantification of cell proliferation was assessed by CCK8 assay kit, and the results are presented in Fig

In Phase II outcomes, twice-weekly treatment with 200 mg atesidorsen was well tolerated and decreased the serum IGF1 concentration by 27.8% at week 14 and 18.7% at week 21 in acromegalic patients